Protein Modification Reagents
Medchemexpress LLC Nhpi-PEG2-C2-NHS ester | 2101206-31-7 | 98.2% | 420.37 g·mol⁻¹ | C19H20N2O9 | 100 MG
NHPI-PEG2-C2-NHS ester is a noncleavable 2-unit polyethylene glycol (PEG) linker bearing an NHPI leaving group and an NHS ester, designed for stable bioconjugation in antibody-drug conjugate (ADC) synthesis.
- Noncleavable 2-unit PEG linker suitable for ADCs and bioconjugation.
- NHS ester functional group enables efficient coupling to primary amines.
- Reported purity 98.23% and molecular weight 420.37 g·mol⁻¹.
- Molecular formula C19H20N2O9; supplied as a solid in 100 MG packages.
Medchemexpress LLC 4,7,10,13-tetraoxa-16-azaheneicosanoic acid, 21-[(3as,4s,6ar)-hexahydro-2-oxo-1h-thieno[3,4 | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 100 MG
Biotin-PEG4-PFP ester is a cleavable four-unit polyethylene glycol (PEG4) biotinylation reagent bearing a pentafluorophenyl (PFP) ester reactive group used for labeling and as an antibody-drug conjugate (ADC) linker. It is supplied for research use only.
- Cleavable PEG4 spacer increases hydrophilicity and reduces steric hindrance.
- PFP ester reactive group enables efficient conjugation to primary and secondary amines.
- High purity (96.18%) and available in multiple pack sizes, including 100 MG.
- Storage: powder at -20°C; in solvent stable at -80°C for 6 months or -20°C for 1 month.
- CAS number 1334172-58-5; molecular weight 657.65 g/mol; formula C27H36F5N3O8S.
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | C40H81N3O20 | 50 MG
Azido-PEG20-alcohol | 1637297-21-2 | C40H81N3O20 | 50 MG
![eMolecules 113072-75-6 | Biotin-PEG5-amine | Broadpharm | MFCD22574819 | 506.660 | C22H42N4O7S | 98.000 | NCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 309209149](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502202951.JPG-250.jpg)
eMolecules 113072-75-6 | Biotin-PEG5-amine | Broadpharm | MFCD22574819 | 506.660 | C22H42N4O7S | 98.000 | NCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 309209149
Biotin-PEG5-amine | Broadpharm | 113072-75-6 | MFCD22574819 | 506.660 | C22H42N4O7S | 98.000 | NCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 309209149
Medchemexpress LLC DNP-PEG4-DBCO | 2149585-17-9 | 97.0% | C35H39N5O10 | 100 MG
DNP-PEG4-DBCO | 2149585-17-9 | 97.0% | C35H39N5O10 | 100 MG
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | >98.0% | 634.56 g/mol | C24H48BrN3O11 | 100 MG
N3-PEG11-CH2CH2Br is an azide-terminated polyethylene glycol (PEG11) linker bearing a terminal bromoethyl group. Supplied as a high-purity research reagent (purity >98%), it is intended for bioconjugation, probe synthesis, and other linker chemistry where azide reactivity and alkyl bromide substitution are required. The hydrophilic PEG spacer enhances solubility in aqueous media, facilitating handling in biochemical assays. Typical pack size: 100 mg.
- Azide-terminated linker for click chemistry.
- Terminal bromoethyl group enables nucleophilic substitution.
- PEG11 spacer improves aqueous solubility.
- High purity suitable for research applications.
- Supplied in small-scale vials for synthesis and probe development.
Medchemexpress LLC (S,R,S)-Ahpc-peg2-n3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 10 MG
(S,R,S)-AHPC-PEG2-N3 is a VHL E3 ligase ligand-linker conjugate that incorporates an (S,R,S)-AHPC-based VHL ligand linked to a two-unit PEG spacer terminating in an azide group. It is supplied as a research reagent for use in PROTAC development and for click-chemistry conjugation.
- VHL E3 ligase ligand-linker conjugate.
- Azide terminal group for click chemistry conjugation.
- Two-unit PEG spacer provides a flexible linker.
- Molecular weight 601.72 g/mol.
- Soluble in DMSO (125 mg/mL) and ethanol (50 mg/mL); ultrasonic assistance recommended.
- Store at -20°C under nitrogen; in solvent, store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Azide-PEG4-Tos | 168640-82-2 | 99.6% | C15H23N3O6S | 250 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, enabling various bioconjugation strategies.
- Contains an azide group for click chemistry reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- Useful for the synthesis of PROTACs.
Medchemexpress LLC Bromo-PEG4-azide | 1951439-37-4 | 98.1% | C10H20BrN3O4 | 250 MG
Bromo-PEG4-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 100 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Medchemexpress LLC 4-Arm PEG-SCM MW 10 1g
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
Medchemexpress LLC DMG-PEG-NHS, MW 2000 | 95.0% | 2000 | 5 MG
DMG-PEG-NHS, MW 2000 is a compound composed of Myristic acid (HY-N2041) and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain.
- Used for protein/biomolecule modification.
- Supports gene delivery.
- Applicable in biosensor applications.
Medchemexpress LLC Mal-Ph-CONH-PEG4-NHS ester | 1263044-88-7 | 561.54 | 1 G
Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable 4 unit PEG ADC linker designed for the synthesis of antibody-drug conjugates (ADCs).
- Non-cleavable linker
- 4 unit PEG
- Used in antibody-drug conjugate synthesis